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This is a retrospective review of 65 consecutive men treated at 2 institutions with salvage Pd-103 prostate seed implants between May 1992 and June 2004. All men had previously been treated with external radiation with doses ranging from 6300cGy - 7380 cGy. All had biopsy proven disease in the prostate with negative CT scan and Bone scan staging studies. All men were treated with a Real-Time Intra-Operative Dosimetry Technique. 95% of men received short term neoadjuvant hormonal therapy with an LHRH agonist. Serial PSA levels were obtained at follow-up and treatment related toxicities were recorded according to the RTOG late toxicity grading scale. Biochemical failure was defined according to the ASTRO Consensus
definition of 3 consecutive rises in PSA.