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From May 2001 to July 2005, 55 patients with OCSCC were treated with IMRT for curative intent. Fifty patients received postoperative IMRT; of these, 3 received concurrent chemotherapy. Five were treated primarily with definitive IMRT.
Sites included were:
- oral tongue (20)
- floor of mouth (15)
- buccal mucosa (6)
- retromolar trigone (6)
- alveolar ridge (6)
- lip (2)
Three target volumes (CTV1, CTV2, and CTV3) were defined.
- For the definitive cohort, the prescribed doses to CTV1, CTV2, and CTV3 were 70 Gy, 60 Gy, and 54 Gy respectively.
- For high-risk postoperative IMRT, the prescribed doses to CTV1, CTV2, and CTV3 were 64-66 Gy, 60 Gy and 54 Gy respectively.
- For intermediate-risk postoperative IMRT, the prescribed doses to CTV1, CTV2 and CTV3 were 60 Gy, 60 Gy and 54 Gy.
The failure patterns were determined by co-registration or comparison of the treatment planning CT to the CT or MRI obtained at the time of recurrence.
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