Abstract # 1049 Histone Deacetylase Inhibitor LBH589 Radiosensitizes Non-Small Cell Lung Cancer by Inhibiting DNA Repair

Presenter: Cuneo, Kyle

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Histone deacetylases (HDACs) have been identified as therapeutic targets due to their important regulatory function in DNA structure and organization. In addition to promoting growth arrest by themselves, HDAC inhibitors have been shown to have synergistic effects with cytotoxic cancer therapy. Non-small cell lung cancer (NSCLC) is often refractory to treatment and resistant to non-surgical treatment modalities. In the current study the effect of the novel HDAC inhibitor LBH589 on NSCLC was examined.

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