Abstract # 2508 Intensity-modulated Radiation Therapy (IMRT) for Non-small Cell Lung Cancer (NSCLC): Treatment Outcomes from a Small, Elderly Cohort

Presenter: Scarbrough, Todd

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OS and FFP for the 24 patient cohort, with outcomes by stage group, are shown in Figure 4 (All figures are shown in the attached poster PDF). Method of simulation and treatment (gating/DIBH vs. FB) seem to have an affect on FFP but do not significantly affect survival (see Figure 5). PET response appears to be significantly prognostic for both OS and FFP (see Figure 5). The overall survival for Stage IIIA/B patients treated with gating/DIBH, or achieving PET CR, was excellent (100% at 2 years). In Cox hazard modeling, however, no significant treatment method or PET effects are noted, nor are any significant OS or FFP associations noted with any other factors (age, RT dose, normalization, etc.). The only trend towards any significance is the association of PET response and freedom from progression (hazard ratio: 0.14, 95% confidence interval: 0.0171.25; P = 0.074).

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